Inbred Mouse Strains Expression in Primary Immunocytes across Variation and Genetic Control of Gene
نویسندگان
چکیده
Charlie C. Kim and Lewis L. Lanier Natalie A. Bezman, Joseph C. Sun, Gundula Min-Oo, Rossi, Nidhi Malhotra, Katelyn Sylvia, Joonsoo Kang, Koller, David Laidlaw, Jim Collins, Roi Gazit, Derrick J. Daphne Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Jakubzick, Gwendalyn J. Randolph, Paul Monach, Adam J. Brown, Miriam Merad, Emmanuel L. Gautier, Claudia Deepali Malhotra, Shannon Turley, Jennifer Miller, Brian Fletcher, Kutlu Elpek, Angelique Bellemare-Pelletier, Mathis, Christophe Benoist, Taras Kreslavsky, Anne Ericson, Katherine Rothamel, Adriana Ortiz-Lopez, Diane Tata Nageswara Rao, Amy Wagers, Tracy Heng, Jeffrey Cohen, Patrick Brennan, Michael Brenner, Francis Kim, Shinton, Richard R. Hardy, Tal Shay, Aviv Regev, Nadia Consortium, David A. Blair, Michael L. Dustin, Susan A. Christophe Benoist, The Immunological Genome Kimie Hattori, Cristina Pop, Daphne Koller, Diane Mathis, Sara Mostafavi, Adriana Ortiz-Lopez, Molly A. Bogue,
منابع مشابه
Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains.
To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological Genome Project, gene expression profiling for CD4(+) T cells and neutrophils purified from 39 inbred strains of the Mouse Phenome Database. Considering both cell types, a large number of transcripts showed significant variation across th...
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Behaviors are often highly heritable, polygenic traits. To investigate molecular mediators of behavior, we analyzed gene expression patterns across seven brain regions (amygdala, basal ganglia, cerebellum, frontal cortex, hippocampus, cingulate cortex, and olfactory bulb) of 10 different inbred mouse strains (129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BTBR T+ tf/J, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, a...
متن کاملLarge scale gene expression differences across brain regions and inbred strain correlate with behavioral phenotype
Behaviors are often highly heritable, polygenic traits. To investigate molecular mediators of behavior, we analyzed gene expression patterns across seven brain regions (amygdala, basal ganglia, cerebellum, frontal cortex, hippocampus, cingulate cortex and olfactory bulb) of ten different inbred mouse strains (129S1 variation was observed across both strain and brain region. These data provide p...
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Among inbred mouse strains there is a striking genetic variation in the levels of apolipoprotein A-IV (apoA-IV) mRNA in the liver, although intestinal mRNA levels vary only twofold in these strains. In the present study we have characterized the apoA-IV expression phenotypes in strains C57BL/6J and 129/J, and investigated the molecular basis for the genetic variation. We report that the two str...
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The laboratory mouse is the most widely used mammalian model organism in biomedical research, so a thorough annotation of functional variation in the mouse genome would be of significant value. In this study, we compared sequence variation in a comprehensive list of functional elements (e.g. promoters, enhancers and CTCF binding sites) across 17 inbred mouse strains. Sequences were derived for ...
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